Transformative Digestive Health under the Leadership of Asaf Bar

Redefining the future of digestive health with its innovative solutions, Vibrant Gastro is a pioneering novel approach to treating constipation through mechanical stimulation. Founded in 2007, the company is committed to bridging the healthcare gap and delivering cutting edge, drug-free treatments in digestive health.

As a trailblazer in the field, Vibrant Gastro designed and executed a comprehensive clinical research program to investigate the potential of specific mechanical stimulation parameters in safely and effectively improving bowel function in patients with chronic idiopathic constipation (CIC).

Through multiple double-blind, placebo-controlled studies, Vibrant Gastro evaluated both the mechanism of action and optimal dosing, with over 800 CIC patients participating in U.S.-based trials, including a successful Phase III study involving more than 300 participants.

Backed by committed investors and a dedicated team, Vibrant Gastro set out to demonstrate that synchronizing treatment with the body’s natural biological rhythms could deliver meaningful clinical benefits, offering constipated patients a drug-free solution that improves symptoms and enhances quality of life.

Asaf’s Story: A Journey of Notable Transformation

Asaf’s journey has been driven by a passion for bringing transformative technologies to life, and Vibrant Gastro represents a rare convergence of engineering, neuroscience, and genuine patient needs. Chronic constipation affects tens of millions in the US alone, yet traditional options often fall short of delivering sustainable relief. Upon seeing the team’s innovative, drug-free approach that stimulates the gut-brain connection, Asaf knew they were on the cusp of something extraordinary.

As CEO, he is dedicated to scaling this vision with a strong commitment to clinical rigor, regulatory clarity, and a holistic view of the patient. Every day, he hears from individuals whose lives have been transformed by the therapy, people who have regained a sense of control, confidence, and comfort. That’s why they do what they do. This purpose-driven work is what fuels Vibrant Gastro’s story of persistence, partnership, and progress.

The Genesis of Vibrant’s Micro-Vibration Capsule Technology

The development of Vibrant Gastro’s distinctive micro vibration capsule technology was inspired by the significant unmet need for therapy for chronic constipation.

Studies led by experts such as William D. Chey, MD (University of Michigan); Anthony J. Lembo, MD (Cleveland Clinic); Satish Rao, MD (MCG and Augusta University Health); and Eamonn Quigley (Houston Methodist) report that nearly 60% of patients are dissatisfied with current treatments and are open to trying new options.

In response, Vibrant Gastro offers a novel, drug-free approach that uses gentle, pre-programmed vibrations to stimulate natural colonic contractions. This mechanical stimulation helps propel contents through the colon, enhancing motility in sync with the body’s biological rhythms.

Clinical studies have demonstrated the efficacy of Vibrant Gastro in improving continuous spontaneous bowel movements (CSBMs), reducing straining, and enhancing quality of life by helping patients regain predictable control of their bodies. Remarkably, efficacy didn’t come hand in hand with high rates of side effects, most common with drug-based therapies for CIC. Diarrhea, the most bothersome side effect was significantly lower with the Vibrant System compared to other drugs in the space.

An Innovative Approach to Constipation Treatment

The Vibrant System’s bioelectronic, ingestible capsule works differently from traditional drug-based constipation treatments. After programming, the capsule transits the stomach and small intestine, then activates in the colon 14 hours later, emitting gentle vibrations against the colon wall. This stimulation excites the mechanical receptors within the colon, resetting the natural biorhythm and inducing a peristaltic effect to help push out its contents.

Patient Feedback and Data-Driven Evolution 

Vibrant Gastro’s product and approach have evolved with patient feedback and data. The company’s digital component, including a companion app, enables patients to report results, track growth, and get reminders, resulting in better treatment results. With significant app usage of around 60%, Vibrant Gastro collects valuable post-market data, offering insights into patients’ behavior and the disease. This data-driven approach allows Vibrant Gastro to tailor its solutions to patient needs while giving clinicians confidence in the care being delivered. The continuous feedback loop has been instrumental in refining the technology and improving patient outcomes.

Supporting Patients’ Transition to a Natural Solution

Asaf acknowledges that CIC patients often try new medication combinations to alleviate their symptoms. When using the Vibrant system, patients have flexibility in managing their treatment plan. Based on post-market data, some patients discontinue all other medications, while others gradually wean themselves off, occasionally using over-the-counter medications as needed. Ultimately, patients tend to settle on a regimen that is suitable for them, with some relying solely on the Vibrant system. This approach enables individuals to tailor their treatment to their distinctive needs and preferences.

Future Outlook: Expanding Vibrant Gastro’s Impact 

Vibrant Gastro’s tech platform enables future opportunities for developing data-driven personalized treatment and additional indications, leveraging the gut-brain connection via the Enteric Nervous System (ENS) pathway. The company’s first indication is for treating adults with chronic idiopathic constipation (CIC) who have not experienced relief of their bowel symptoms by using laxative therapies at the recommended dosage for at least one month.

With FDA clearance for CIC, which affects somewhere north of 39 million people in the US, Vibrant Gastro is currently focused on this largest segment of the constipation market. Its initial clinical trial was done on CIC patients. It will seek additional labeling for other indications in the future, but right now, that application is by far the largest portion of the chronic constipation market.

Scaling Access and Awareness

Vibrant aims to scale its U.S. presence nationwide and expand globally over the next five years. The company’s innovative micro‑vibration capsule provides a drug‑free solution for chronic idiopathic constipation patients with the additional benefit of no interactions with other medications.

Vibrant Gastro is working to raise awareness and access to its drug-free option for chronic constipation through multiple strategies. These include direct-to-patient education, forming strong physician partnerships, and implementing expanded access initiatives. By combining clinical credibility with sharing real patient stories, the company aims to make Vibrant Gastro a first-line consideration for those struggling with symptoms.

Exploring Strategic Partnerships

Vibrant Gastro is open to opportunities that align with its mission to improve access and outcomes for patients with chronic idiopathic constipation. While no specific partnerships have been announced, the company sees potential for collaboration with larger healthcare systems, digital health platforms, and pharma companies. Through these opportunities, Vibrant Gastro aspires to accelerate its impact and deliver innovative solutions.

The Biggest Leadership Lesson

Asaf’s journey introducing Vibrant Gastro’s innovative health product to the market has taught him a valuable leadership lesson: the importance of listening to the patient’s journey. By carefully understanding the needs, requirements, and aspirations of individuals affected by chronic constipation, the company has gained valuable insights into how to better meet their needs. This patient-centric approach has instilled humility in the company. The team continues to search for answers to relieve patients from the challenges they currently have. Vibrant Gastro’s commitment to delivering a top-notch patient experience is visible in its ‘white glove treatment’ approach, demonstrating its dedication to offering excellent care and support.

Driving Innovation and Empowerment

Vibrant’s mission resonates deeply with Asaf’s passion for innovation and patient advocacy. With a career dedicated to developing solutions that address unmet medical needs and empower patients, Asaf is driven by the company’s groundbreaking approach to chronic constipation treatment.

What inspires Asaf most about Vibrant Gastro is how the team is pushing the boundaries of what’s possible through a drug-free, science-driven approach that taps into the gut-brain connection to deliver real, predictable relief. Vibrant Gastro’s technology provides patients a chance to regain control over their lives, restoring dignity, confidence, and quality of life.

Vibrant Gastro’s Five-Year Vision

Vibrant Gastro is set to scale its U.S. presence nationwide and expand globally over the next five years. The company’s innovative micro-vibration capsule provides a drug-free solution for chronic idiopathic constipation patients with the additional benefit of no interactions with other medications. By increasing access to its technology, Vibrant Gastro aims to support thousands of patients on their journey to improved digestive health. With its unique approach and commitment to patient results, the company is set to make a notable impact on millions of people’s lives globally.